Marin Cilic (ATP 9), vincitore di cinque partite consecutive senza perdere nemmeno una frazione agli US Open, ha dovuto ricorrere al quinto set per superare il terzo turno di Flushing Meadows. Il campione in carica ha avuto la meglio su Mikhail Kukushkin (56) per 6-7 (5/7) 7-6 (7/1) 6-3 6-7 (3/7) 6-1 in 4h11'. Per due volte a un passo dall'andare sotto per due set a zero, il croato ha salvato la situazione con il servizio contro il kazako.
Dal canto suo Novak Djokovic (1) non ha avuto particolari problemi ad archiviare la pendenza Andreas Seppi (25). Il serbo ha mandato a casa l'italiano con il risultato di 6-3 7-5 7-5.
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