L'urna di Nyon ha regalato una doppia sfida tra Italia e Germania nei 1/16 di finale di Europa League. Il Napoli affronterà il Lipsia, attualmente secondo nella classifica di Bundesliga, mentre l'Atalanta sfiderà il Borussia Dortmund. Meglio è andata al Milan, opposto ai bulgari del Ludogorets, ed alla Lazio, sorteggiata con i rumeni della Steaua Bucarest, già avversari del Lugano nella fase a gironi.
L'Atletico Madrid, grande esclusa dalla Champions League, giocherà contro i danesi del Copenaghen, mentre l'Arsenal di Xhaka affronterà gli svedesi dell'Östersund. Da segnalare anche Nizza-Lokomotiv Mosca, Spartak Mosca-Athletic Bilbao, Lione-Villarreal, Real Sociedad-Salisburgo e Marsiglia-Braga.
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