Nel GP del Brasile, il penultimo della stagione, il primo a tagliare il traguardo è stato il fresco Campione del Mondo Lewis Hamilton, al decimo successo in stagione. Con questa vittoria e il buon quinto posto di Valtteri Bottas la Mercedes si mette in tasca il titolo costruttori (il quinto consecutivo), visto che le Ferrari si sono dovute accontentare della terza piazza di Kimi Raikkonen e della sesta di Sebastian Vettel. Sul secondo gradino del podio è invece salito Max Verstappen, nonostante un contatto con il doppiato Esteban Ocon al 44o giro, mentre il suo compagno di scuderia Daniel Ricciardo ha terminato quarto.
Dietro ai sei piloti delle tre migliori scuderie è arrivato un ottimo Charles Leclerc con la sua Sauber Alfa-Romeo, mentre l'altra monoposto elvetica di Marcus Ericsson ha abbandonato la gara al 22o giro.
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