Prima che la pioggia arrivasse a rovinare tutti i piani, a Cincinnati non sono mancate le sorprese: 3 delle prime 10 teste di serie del tabellone femminile sono infatti state eliminate! Unica a salvarsi è stata Petra Kvitova (6), sbarcata ai quarti di finale grazie al 6-4 6-2 su Kristina Mladenovic (57).
Al termine di un match combattuto, la ex numero uno del mondo Angie Kerber (4) si è arresa 2-6 7-6 (7/3) 6-4 a Madison Keys (13). Anche Caroline Garcia (5) ha perso in tre set (6-4 3-6 7-5) da Aryna Sabalenka (34), mentre Sloane Stephens (3) non è riuscita a superare l'ostacolo Elise Mertens (14), inchinandosi con il punteggio di 7-6 (10/8) 6-2.
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