Carlos Alcaraz (ATP 6) e Alexander Zverev (3) hanno rischiato di compromettere il loro cammino al Roland Garros, ma alla fine sono stati capaci di superare il secondo impegno in terra parigina. Uno dei favoriti alla vittoria finale, lo spagnolo ha piegato la resistenza del connazionale Albert Ramos-Vinolas (44) con il risultato di 6-1 6-7 (7/9) 5-7 7-6 (7/2) 6-4 dopo 4h 38'. Un pizzico più fortunato il tedesco, impostosi con il punteggio di 2-6 4-6 6-1 6-2 7-5 sull'argentino Sebastian Baez (36) nell'altra maratona di giornata durata 3h39'.
Ha faticato, perlomeno nel terzo set, anche Novak Djokovic (1) prima di battere con i parziali di 6-2 6-3 7-6 (7/4) lo slovacco Alex Molcan (38). Più semplice il compito di Rafael Nadal (5), liberatosi facilmente del giustiziere di Stan Wawrinka (264) nel primo turno. Il maiorchino ha infatti rifilato un secco 6-3 6-1 6-4 al francese Corentin Moutet (139). Ha raggiunto per la prima volta nella sua carriera il terzo turno dell'Open di Francia pure Félix Auger-Aliassime (9), capace a sua volta di superare 6-0 6-3 6-4 l'argentino Camilo Ugo Carabelli (115).
In campo femminile invece altra eliminazione di spicco: dopo Barbora Krejcikova (WTA 2), Anett Kontaveit (5), Ons Jabeur (6) e Garbine Muguruza (10), anche Maria Sakkari (3) ha salutato anticipatamente il torneo parigino. La semifinalista dell'ultima edizione è infatti stata sconfitta con il risultato di 7-6 (7/5) 7-6 (7/4) dalla ceca Karolina Muchova (81), lasciando così la parte bassa del tabellone senza più top ten.
Tutte le partite del Roland Garros non diffuse dalla RSI sono visibili su Eurosport Player.
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