Il Masters 1000 di Madrid ha già perso la testa di serie numero 11 del tabellone. Al secondo turno il canadese Denis Shapovalov (ATP 14) si è fatto sorprendere dal talentuoso kazako Alexander Bublik (44), impostosi al termine di una battaglia di quasi 2h20' con il risultato di 6-4 5-7 6-4.
Già promossi agli ottavi di finale anche l'italiano Matteo Berrettini (10), che si è fatto bastare un break per set per avere la meglio con un più agevole 6-3 6-4 nel derby contro Fabio Fognini (28), e il russo Andrey Rublev (7), che ha piegato 6-7 (5/7) 6-3 6-4 l'americano Tommy Paul (58). In serata nessun problema nemmeno per Dominic Thiem (4). Al rientro sul circuito dopo qualche settimana di pausa, l'austriaco ha liquidato lo statunitense Marcos Giron (91) per 6-1 6-3.
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