È finita una serie di nove successi consecutivi per il Brasile, fermato sullo 0-0 dalla Colombia nelle decima partita delle qualificazioni sudamericane ai Mondiali 2022. A Barranquilla i Verdeoro, con in campo Neymar, hanno iniziato con il piede premuto sull'acceleratore ma non sono riusciti a firmare la prima rete del match. La prima posizione in classifica, e il pass per la rassegna, è ormai però consolidata.
L'Argentina ha prontamente riscattato il passo falso accusato contro il Paraguay e sconfitto in scioltezza, 3-0, l'Uruguay. Al Monumental di Buenos Aires è proprio stata l'Albiceleste a farsi preferire, colpendo ripetutamente i legni, ma per sbloccare la contesa è stata necessaria una fortunosa rete di Messi. A rimpinguare il parziale sono poi stati De Paul e Lautaro, permettendo così all'Argentina di rosicchiare due punti e consolidare il secondo posto.
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